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This novel fibrinolytic and proteolytic enzyme, named nattokinase, was easily extracted with saline.”1 Fibrinolytic agents are capable of stimulating the dissolution of a blood clot.
Early Research with Nattokinase
Nattokinase has been on the market to the public since 1998. In 1990, the study group which described nattokinase’s ability to lower clotting stated that nattokinase taken orally by dogs enhanced the capability of blood plasma to break down fibrin. Fibrin is a protein formed by the action of thrombin on fibrinogen which is involved with the creation of blood clotting. 2 This fibrinolytic action of Nattokinase will help prevent blood clots from growing and becoming damaging.
When scientists stimulated blood clots within the common carotid artery of rats, healing time of arterial blood flow in nattokinase-treated animals was greater than three times that belonging to the administration of plasmin, that is produced by the body to dissolve fibrin blood clotting. 3. In another rat study, supplementation with nattokinase 3 weeks pre and post endothelial damage to the femoral artery resulted in increased suppression of intimal thickening and dissolution of blood clots close to the site of injury in comparison to control animals that didn’t receive the dietary supplement. 4. Yet another rat study discovered a dose-dependent delay within induced arterial occlusion associated with nattokinase. 5. Nattokinase at a high dose was discovered to totally reduce the actual occlusion, very similar to the power of aspirin.
Recent experimental data shows that nattokinase may be valuable in the management of Alzheimer’s disease. 6. Rats ingested aluminum chloride for Forty-five days, which elevated the activity involving brain acetylcholinesterase (an enzyme which breaks down the neurotransmitter acetylcholine) and induced other adverse changes, including neuronal degeneration inside the hippocampus as well as amyloid plaque development. However, oral administration of nattokinase or another proteolytic enzyme known as serrapeptase decreased these results, which suggests the need for further analysis regarding their possible use for Alzheimer’s disease patients.